N-Alkylation of poor nucleophilic amines and derivatives with alcohols by a hydrogen autotransfer process catalyzed by copper (II) acetate: scope and mechanistic …
A Martínez-Asencio, DJ Ramón, M Yus
Index: Martinez-Asencio, Ana; Ramon, Diego J.; Yus, Miguel Tetrahedron, 2011 , vol. 67, # 17 p. 3140 - 3149
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Citation Number: 71
Abstract
Copper (II) acetate is a versatile, cheap and simple catalyst for the selective N- monoalkylation of amino derivatives with poor nucleophilic character, such as aromatic and heteroaromatic amines as well as carboxamides, phosphinamides, sulfonamides, and phosphazenes, using in all cases primary alcohols as initial source of the electrophiles, through a hydrogen autotransfer process. In the case of sulfonamides, the monoalkylation ...
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