Acylation of Diethyl Phosphonoacetic Acid Via the MgCl2/Et3N System: A Practical Synthesis of β-Keto Phosphonates

…, I L'Hostis-Kervella, JP Haelters

Index: Corbel, Bernard; L'Hostis-Kervella, Isabelle; Haelters, Jean-Pierre Synthetic Communications, 2000 , vol. 30, # 4 p. 609 - 618

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Citation Number: 11

Abstract

Abstract A one pot simple procedure for the synthesis of β-keto phosphonates has been developed using the MgCl2/Et3N base system to generate the magnesium enolate of diethyl phosphonoacetic acid. This intermediate reacts with acid chlorides or imidazolides to give, after workup, the title compounds in good yields.

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