Light effect on the stability of β??lapachone in solution: pathways and kinetics of degradation
…, A Estévez??Braun, E Pérez??Sacau…
Index: Cunha-Filho, Marcilio S.S.; Estevez-Braun, Ana; Perez-Sacau, Elisa; Echezarreta-Lopez, Ma Magdalena; Martinez-Pacheco, Ramon; Landin, Mariana Journal of Pharmacy and Pharmacology, 2011 , vol. 63, # 9 p. 1156 - 1160
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Citation Number: 5
Abstract
Objectives The purpose of this work was to study the chemical stability of the new antitumoral β-lapachone (βLAP) to determine the degradation pathway/s of the molecule and the degradation kinetics in addition to identifying several degradation products. Method Samples of βLAP in solution were stored under conditions of darkness and illumination at 40 C at which the pseudo-first order rate constants for the βLAP degradation were ...
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