Tetrahedron letters

Synthesis and antiretroviral evaluation of 3-alkyl 2-piperazinone nucleoside analogs

A Benjahad, R Benhaddou, R Granet, M Kaouadji…

Index: Benjahad, Abdellah; Benhaddou, Rachida; Granet, Robert; Kaouadji, Mourad; Krausz, Pierre; et al. Tetrahedron Letters, 1994 , vol. 35, # 51 p. 9545 - 9548

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Citation Number: 13

Abstract

Abstract Glycosylation of 3-alkyl N 4-(3-hydroxypropyl) 2-piperazinones by protected 1-O- acetyl ribofuranoses produces nucleoside analogs in which the base is separated from the sugar by a hydrocarbon spacer arm. The preliminary in vitro test results against retroviruses seem promising for compounds bearing a long alkyl chain.