Synthesis of nordihydroguaiaretic acid derivatives and their bioactivities on S. pombe and K562 cell lines
X Li, JH Jiang, Q Chen, SX Xiao, CH Li, HW Gu…
Index: Li, Xu; Jiang, Jian-Hong; Chen, Qingqi; Xiao, Sheng-Xiong; Li, Chuan-Hua; Gu, Hui-Wen; Zhang, Hui; Hu, Ji-Lin; Yao, Fei-Hong; Li, Qiang-Guo European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 605 - 613
Full Text: HTML
Citation Number: 6
Abstract
Nordihydroguaiaretic acid (NDGA) and its synthetic analogues are potentially useful in treating diseases related to cancers, diabetes, viral and bacterial infections, and inflammation. In this paper, we report the optimal synthetic methods and the bioactivity study of terameprocol 2, NDGA derivative 3, and its cyclized analogue 4. The IC50 of these three compounds 2, 3 and 4 on the growth metabolism of Schizosacchromyces pombe and ...
Related Articles:
DMF as Carbon Source: Rh-Catalyzed α-Methylation of Ketones
[Li, Yang; Xue, Dong; Lu, Wei; Wang, Chao; Liu, Zhao-Tie; Xiao, Jianliang Organic Letters, 2014 , vol. 16, # 1 p. 66 - 69]
Cyclization of diketones to pyridazine and furan derivatives
[Allah, Hassan M. Faid; Soliman, Raafat Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1745 - 1748]
[Joshi, Bhupendra P.; Sharma, Anuj; Sinha, Arun K. Canadian Journal of Chemistry, 2005 , vol. 83, # 10 p. 1826 - 1832]
Mechanism of isomerization of 4-propyl-o-quinone to its tautomeric p-quinone methide
[Chemical Research in Toxicology, , vol. 9, # 1 p. 109 - 113]
Mechanism of isomerization of 4-propyl-o-quinone to its tautomeric p-quinone methide
[Chemical Research in Toxicology, , vol. 9, # 1 p. 109 - 113]