Direct preparation of polyfunctional amino-substituted arylmagnesium reagents via an iodine–magnesium exchange reaction

…, C Kofink, DM Lindsay, A Ricci, P Knochel

Index: Varchi, Greta; Kofink, Christiane; Lindsay, David M.; Ricci, Alfredo; Knochel, Paul Chemical Communications, 2003 , # 3 p. 396 - 397

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Citation Number: 22

Abstract

The generation of functionalised aryl- and heteroaryl-magnesium reagents is an important advance in organic synthesis. 1 An especially important class of functionalised arylmagnesium compounds are those bearing an amino group, since these reagents allow further elaboration to heterocycles or to target molecules for the pharmaceutical or agrochemical industry. Recently, we have reported that the iodine–magnesium exchange 2 reaction allows the synthesis of protected ...