Efficient Synthesis of Deazaguanosine??Derived tRNA Nucleosides PreQ0, PreQ1, and Archaeosine Using the Turbo??Grignard Method

…, I Thoma, AJ Wagner, P Knochel…

Index: Brueckl, Tobias; Thoma, Ines; Wagner, Andreas J.; Knochel, Paul; Carell, Thomas European Journal of Organic Chemistry, 2010 , # 34 p. 6517 - 6519

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Citation Number: 12

Abstract

Abstract The natural products PreQ 1, PreQ 0, and archaeosine are deazaguanosine- derived natural products of immense biological importance. All three are critical components of tRNAs and, as such, are involved in decoding genetic information. We were able to consolidate and shorten the syntheses of all three compounds by using a novel Turbo- Grignard-based approach. The reported iodine/magnesium exchange followed by a ...

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