Tetrahedron

Comparative study of synthetic approaches to 1-arylmethylenepyrazino [2, 1-b] quinazoline-3, 6-diones

P Cledera, C Avendaño, JC Menéndez

Index: Cledera, Pilar; Avendano, Carmen; Menendez, J. Carlos Tetrahedron, 1998 , vol. 54, # 40 p. 12349 - 12360

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Citation Number: 35

Abstract

The transformation of 3-arylmethylenepiperazine-2, 5-diones (1) into 1-arylmethylene-2, 4- dihydro-1H-pyrazino [2, 1-b] quinazoline-3, 6-diones (2) was studied. Four synthetic methods were compared, namely direct condensation with the product of the reaction between anthranilic acid and thionyl chloride, transformation into monothioiminoethers or monoiminoethers followed by reaction with anthranilic acid derivatives, and ...

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