Archiv der Pharmazie

Synthesis and In??vitro Antimicrobial Activity of Secondary and Tertiary Amines Containing 2??Chloro??6??methylquinoline Moiety

S Kumar, S Bawa, D Kaushik…

Index: Kumar, Suresh; Bawa, Sandhya; Kaushik, Darpan; Panda, Bibhu P. Archiv der Pharmazie, 2011 , vol. 344, # 7 p. 474 - 480

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Abstract

Abstract A number of secondary and tertiary amines bearing 2-chloro-6-methylquinoline were synthesized by nucleophilic substitution reaction of 3-(chloromethyl)-2-chloro-6- methylquinoline with substituted aromatic primary and secondary amines in presence of catalytic amount of triethylamine (TEA) and K 2 CO 3. All the compounds were characterized by combined use of IR, 1 H-NMR, 13 C-NMR, mass spectral data, and microanalyses. The ...