Cytochrome P450 2C9 type II binding studies on quinoline-4-carboxamide analogues

…, T Rushmore, GJ Crouch, JP Jones

Index: Peng, Chi-Chi; Cape, Jonathan L.; Rushmore, Tom; Crouch, Gregory J.; Jones, Jeffrey P. Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 8000 - 8011

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Citation Number: 26

Abstract

CYP2C9 is a significant P450 protein responsible for drug metabolism. With the increased use of heterocyclic compounds in drug design, a rapid and efficient predrug screening of these potential type II binding compounds is essential to avoid adverse drug reactions. To understand binding modes, we use quinoline-4-carboxamide analogues to study the factors that determine the structure− activity relationships. The results of this study suggest that ...