Search for histamine H3 receptor antagonists with combined inhibitory potency at N τ-methyltransferase: ether derivatives

…, JM Arrang, JC Schwartz, W Schunack…

Index: Apelt; Grassmann; Ligneau; Pertz; Ganellin; Arrang; Schwartz; Schunack; Stark, Holger Pharmazie, 2005 , vol. 60, # 2 p. 97 - 106

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Citation Number: 25

Abstract

With the recent development of new hybrid compounds having histamine H3 receptor antagonist with combined histamine N τ-methyltransferase (HMT) inhibitory potency an innovative approach was described in the research of novel lead compounds modulating histaminergic neurotransmission. Several compounds containing an ether moiety derived from the recently published 4-(3-piperidinopropoxy) phenylaminoquinoline derivatives ( ...