Preparation of benzo [c][2, 7] naphthyridin??5 (1H)??ones as analogs of benzopyrano [3, 4??c] pyridin??5??one bronchodilators

PC Unangst, DT Connor, ME Carethers…

Index: Unangst; Connor; Carethers; et al. Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 941 - 944

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Abstract

Abstract A series of 2, 3, 4, 6-tetrahydro-8, 9-dimethoxybenzo [c][2, 7] naphthyridin-5 (1H)- ones was prepared as potential anticholinergic bronchodilators. The naphthyridine ring system was constructed by cyclization of a 3-amido-4-piperidone. Alkylation with alkylaminoethyl chlorides or reductive amination of an intermediate methyl ketone yielded the final target compounds.

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