Decomposition of N-phosphorylated nitrogen mustards: a mechanistic investigation

C le Roux, AM Modro, TA Modro

Index: Roux, Charlotte le; Modro, Agnes M.; Modro, Tomasz A. Journal of Organic Chemistry, 1995 , vol. 60, # 12 p. 3832 - 3839

Full Text: HTML

Citation Number: 13

Abstract

Lithium methyl N-(2-chloroethyl) phosphoramidate (2b) and lithium methyl N, N-bis (2- chloroethyl)-phosphoramidate (2c) were prepared as models of N-phosphorylated mustards used in cancer chemotherapy. The decomposition of those substrates in DzO and in DzO- pyridine-d6 was studied to elucidate the mechanism of their alkylating reactivity. The products of the decomposition and the variation of the proportions of the products with ...

Related Articles:

Size-Specific, Dissociative Activation of Carbon Dioxide by Cobalt Cluster Anions

[Wu, Yichen; Liu, Guosheng Tetrahedron Letters, 2011 , vol. 52, # 48 p. 6450 - 6452]

Cyclodehydration of N-and C-substituted. beta.-amino alcohols to the corresponding aziridines with diethoxytriphenylphosphorane

[Kelly, Jeffery W.; Eskew, Nita L.; Evans, Slayton A. Journal of Organic Chemistry, 1986 , vol. 51, # 1 p. 95 - 97]

Enhanced Product Selectivity in Continuous N??Methylation of Amino Alcohols over Solid Acid–Base Catalysts with Supercritical Methanol

[Angewandte Chemie - International Edition, , vol. 41, # 18 p. 3476 - 3479]

Continuous chemoselective methylation of functionalized amines and diols with supercritical methanol over solid acid and acid-base bifunctional catalysts

[Journal of the American Chemical Society, , vol. 126, # 23 p. 7368 - 7377]

More Articles...