Nucleosides. Part LXI. A Simple Procedure for the Monomethylation of Protected and Unprotected Ribonucleosides in the 2′??O??and 3′??O??Position Using …
H Cramer, W Pfleiderer
Index: Cramer, Hagen; Pfleiderer, Wolfgang Helvetica Chimica Acta, 1996 , vol. 79, # 8 p. 2114 - 2136
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Citation Number: 18
Abstract
Abstract Intensive studies on the diazomethane methylation of the common ribonucleosides uridine, cytidine, adenosine, and guanosine and its derivatives were performed to obtain preferentially the 2′-O-methyl isomers. Methylation of 5′-O-(monomethoxytrityl)-N 2-(4- nitrophenyl) ethoxycarbonyl-O 6-[2-(4-nitrophenyl) ethyl]-guanosine (1) with diazomethane resulted in an almost quantitative yield of the 2′-and 3′-O-methyl isomers which could ...
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