Weakening C− O Bonds: Ti (III), a New Reagent for Alcohol Deoxygenation and Carbonyl Coupling Olefination

…, MM Herrador, JF Quilez del Moral…

Index: Dieguez, Horacio R.; Lopez, Armando; Domingo, Victoriano; Arteaga, Jesus F.; Dobado, Jose A.; Herrador, M. Mar; Quilez Del Moral, Jose F.; Barrero, Alejandro F. Journal of the American Chemical Society, 2010 , vol. 132, # 1 p. 254 - 259

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Citation Number: 50

Abstract

Investigations detailed herein, including density functional theory (DFT) calculations, demonstrate that the formation of either alkoxy− or hydroxy− Ti (III) complexes considerably decreases the energy of activation for C− O bond homolysis. As a consequence of this observation, we described two new synthetic applications of Nugent's reagent in organic chemistry. The first of these applications is an one-step methodology for deoxygenation− ...