Incorporation of a 3-(2, 2, 2-trifluoroethyl)-γ-hydroxy-γ-lactam motif in the side chain of 4-aminoquinolines. Syntheses and antimalarial activities

D Cornut, H Lemoine, O Kanishchev…

Index: Journal of Medicinal Chemistry, , vol. 56, # 1 p. 73 - 83

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Citation Number: 31

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. On the basis of our experience with the synthesis of fluorinated γ-lactams,(18, 22) we envisaged to prepare two series of structures, A and B (Figure 5). The two sets of molecules ...