Tetrahedron

Oligodeoxyribonucleotide synthesis by use of S, S-diphenyl deoxyribonucleoside 3'-phosphorodithioates and bifunctional condensing reagents in the phosphotriester …

M Sekine, JI Matsuzaki

Index: Sekine, Mitsuo; Matsuzaki, Jun-Ichi; Hata, Tsujiaki Tetrahedron, 1985 , vol. 41, # 22 p. 5279 - 5288

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Citation Number: 38

Abstract

Four kinds of arenedisulphonyl chlorides as condensing reagents for oligodeoxyribonucleotide synthesis have been synthesised and their condensing abilities were examined in the synthesis of thymidylyl (3'-5') thymidine. Among them, mesitylenedisulphonyl chloride (MDS) and isodurenedisulphonyl chloride (DDS) proved to be effective for condensation and for separation of the product from the 5'-sulphonated by- ...