Tetrahedron

Homogeneous catalytic aminocarbonylation of nitrogen-containing iodo-heteroaromatics. Synthesis of N-substituted nicotinamide related compounds

A Takács, B Jakab, A Petz, L Kollár

Index: Takacs, Attila; Jakab, Balazs; Petz, Andrea; Kollar, Laszlo Tetrahedron, 2007 , vol. 63, # 41 p. 10372 - 10378

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Citation Number: 29

Abstract

Various primary and secondary amines, including amino acid methyl esters, were used as nucleophiles in palladium-catalysed aminocarbonylation of 2-iodopyridine, 3-iodopyridine and iodopyrazine. N-Substituted nicotinamides and 3-pyridyl-glyoxylamides (2-oxo- carboxamide type derivatives) of potential biological importance can be obtained from 3- iodopyridine as a result of simple and double carbon monoxide insertions, respectively. ...

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