Synthesis of carbamate-linked lipids for gene delivery
D Liu, J Hu, W Qiao, Z Li, S Zhang, L Cheng
Index: Liu, Dongliang; Hu, Jianjun; Qiao, Weihong; Li, Zongshi; Zhang, Shubiao; Cheng, Lvbo Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 12 p. 3147 - 3150
Full Text: HTML
Citation Number: 39
Abstract
Series of lipids 1a–d and 2a, b, with carbamate linkages between hydrocarbon chains and ammonium or tertiary amine head, which were pH sensitive, were synthesized for liposome- mediated gene delivery. The variable length of carbon chains and quaternary ammonium or neutral tertiary amine heads allowed to find the structure–function relationship of how these factors affect cationic lipids on gene delivery performance.
Related Articles:
[Holas, Tomas; Vavrova, Katerina; Sima, Martin; Klimentova, Jana; Hrabalek, Alexandr Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7671 - 7680]
[Plusquellec, Daniel; Roulleau, Fabienne; Lefeuvre, Martine; Brown, Eric Tetrahedron, 1990 , vol. 46, # 2 p. 465 - 474]
[Holas, Tomas; Vavrova, Katerina; Sima, Martin; Klimentova, Jana; Hrabalek, Alexandr Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7671 - 7680]