A new route to amino-2-propanol structures with adrenergic β-blocker activity using low valent titanium
JL Bermudez, C Del Campo, JV Sinisterra, EF Llama
Index: Bermudez; Del Campo; Sinisterra; Llama Tetrahedron Letters, 1997 , vol. 38, # 23 p. 4137 - 4140
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Abstract
Amino-2-propanol structures can be obtained by addition to dibenzyl acetals of in situ generated dihalocarbenes using LVT (Low Valent Titanium). This methodology can be used to obtain adrenergic β-blockers with amino-2-propanol structure. Tetrahalomethanes are the best dihalocarbene precursors. The yields obtained using halofluoromethanes can be increased by addition of carbontetrachloride. A process that can imply halogen transfer ...
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