Synthesis and actions of a melanotropin conjugate, Ac??[Nle4, Glu (gamma??4′??hydroxyanilide) 5, D??Phe7] α??MSH4–10??NH2, on melanocytes and melanoma cells in …

F Al??Obeidi, M Mulcahy, VS Pitt…

Index: Al-Obeidi; Mulcahy; Pitt; Begay; Hadley; Hruby Journal of Pharmaceutical Sciences, 1990 , vol. 79, # 6 p. 500 - 504

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Citation Number: 4

Abstract

Abstract L-Glutamic acid (γ-4′-hydroxyanilide)(GHB) is oxidized by tyrosinase to a quinone which inhibits DNA polymerase, RNA polymerase, and mitochondrial energy production within mushrooms. It was previously shown that GHB can kill B16 melanoma cells in culture, but lacks cytotoxicity for nontyrosinase-containing cells. We have conjugated this drug to a superpotent melanotropic peptide and examined the bioactivity of this conjugate to ...