Tetrahedron Letters

Selectivity between N-1 and N-7 nucleosides: regioselective synthesis of BMK-Y101, a potent cdk7 and 9 inhibitor

YJ Kim, SH Kwon, IH Bae, BM Kim

Index: Kim, Young-Jong; Kwon, Soon Ho; Bae, Il Hak; Kim, B. Moon Tetrahedron Letters, 2013 , vol. 54, # 40 p. 5484 - 5488

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Citation Number: 2

Abstract

Abstract BMK-Y101 is a new pyrrolo [2, 3-d] pyrimidine-based potent cdk7 and 9 inhibitor, which is characterized by an intriguing structural feature of N-1 nucleoside, departing from previously reported N-7 nucleoside Cdk inhibitor, xylocydine. Though N-1 nucleosides have appeared in the literature, they have often been considered as kinetic products and thus intermediates of N-7 glycosylation. In the course of the synthetic studies of xylocydine ...