Veresterung von partiell geschützten peptid-fragmenten mit harzen. Einsatz von 2-chlortritylchlorid zur synthese von Leu 15-gastrin I

…, S Kapolos, G Papaphotiu, W Schäfer, Y Wenqing

Index: Barlos; Gatos; Kapolos; Papaphotiu; Schafer; Wenqing Tetrahedron Letters, 1989 , vol. 30, # 30 p. 3947 - 3950

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Citation Number: 17

Abstract

The esterification of several partially protected peptide fragments through the C-terminal or a free side chain carboxy group with hydroxy groups containing resins and the 2-chlorotritylchloride resin is described. As an application example crude protected Leu 15 - gastrin I ( ) has been obtained in 99% yield by the “solid-phase” method using as the solid support. Crude has been deprotected to free Leu 15 - gastrin ( ) which is thus obtained in 92% yield and 90% purity.