On the Synthesis of Bioisosters of O??Benzothiazolyloxybenzoic Acids and Evaluation as Aldose Reductase Inhibitors

…, P Muigg, N Schröder, B Matuszczak

Index: Rakowitz, Dietmar; Muigg, Patric; Schroeder, Nicole; Matuszczak, Barbara Archiv der Pharmazie, 2005 , vol. 338, # 9 p. 419 - 426

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Citation Number: 8

Abstract

Abstract In continuation of our attempts to develop novel aldose reductase inhibitors (ARIs), a number of compounds characterized by bioisosteric replacement of pharmacophors were prepared. On the one hand, the acidic function was formally replaced by an oxime or a nitro group and on the other hand the lipophilic substituent was modified. The results of the biological evaluation of these derivatives enabled us to gain insight into structural features ...