Microbial transformations of natural antitumor agents. 21. Conversions of aphidicolin

…, J Fuska, A Foskova, JP Rosazza

Index: Ipsen, John; Fuska, Jan; Foskova, A.; Rosazza, John P. Journal of Organic Chemistry, 1982 , vol. 47, # 17 p. 3278 - 3282

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Citation Number: 14

Abstract

Microbial transformations have been employed as a means of preparing analogues of the diterpene aphidicolin. Microbial transformation products were initially identified by thin-layer chromatography of fermentation extracts and then were prepared by larger scale incubations. Each microbial metabolite was subjected to structure elucidation employing carbon-13 and proton NMR, high-resolution mass spectrometry, and infrared analysis. ...