Tetrahedron

Efficient synthesis of aryl hydrazines using copper-catalyzed cross-coupling of aryl halides with hydrazine in PEG-400

J Chen, Y Zhang, W Hao, R Zhang, F Yi

Index: Chen, Junmin; Zhang, Yimin; Hao, Wenyan; Zhang, Rongli; Yi, Fei Tetrahedron, 2013 , vol. 69, # 2 p. 613 - 617

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Citation Number: 6

Abstract

An efficient and convenient method for the synthesis of aryl hydrazines is described via copper-catalyzed cross-coupling of aryl halides with aqueous hydrazine in PEG-400. This protocol is applicable to both electron-deficient and electron-rich aryl iodides and bromides, and even to sterically hindered substrates, giving aryl hydrazines in good to excellent yields.