Tetrahedron

Concise enantioselective synthesis of diospongins A and B

E Stefan, AP Nalin, RE Taylor

Index: Stefan, Eric; Nalin, Ansel P.; Taylor, Richard E. Tetrahedron, 2013 , vol. 69, # 36 p. 7706 - 7712

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Citation Number: 10

Abstract

Abstract Ether transfer methodology is capable of stereoselectively generating 1, 3-diol mono-and diethers in good yield. Surprisingly, allylic and benzylic substrates provide none of the desired products when exposed to previously optimized conditions of iodine monochloride. Herein, second-generation activation conditions for ether transfer have been developed that circumvents undesired side reactions for these substrates. The application ...