Solid phase synthesis of 1, 4-benzodiazepine-2, 5-diones

…, J Zhang, K Bjergarde, DM Lenz, JJ Gaudino

Index: Mayer, John P.; Zhang, Jingwen; Bjergarde, Kirsten; Lenz, Doug M.; Gaudino, John J. Tetrahedron Letters, 1996 , vol. 37, # 45 p. 8081 - 8084

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Citation Number: 105

Abstract

1, 4-benzodiazepine-2, 5-diones were synthesized by a simple procedure utilizing polymer supported amino acids and o-nitrobenzoic acids or protected anthranilic acids. Cyclization of the common aminoamide intermediate with concomitant release from the support furnished the desired 1, 4-benzodiazepine-2, 5-diones. The products were recovered in high yields and exhibited excellent purities.