The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

RW Huigens, S Reyes, CS Reed, C Bunders…

Index: Huigens III, Robert W.; Reyes, Samuel; Reed, Catherine S.; Bunders, Cynthia; Rogers, Steven A.; Steinhauer, Andrew T.; Melander, Christian Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 663 - 674

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Citation Number: 52

Abstract

Multidrug-resistant bacterial infections continue to be a rising global health concern. Herein is described the development of a class of novel 2-aminobenzimidazoles with antibiotic activity. These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains.