Hydration of aromatic terminal alkynes catalyzed by iron (III) sulfate hydrate under chlorine-free conditions
M Bassetti, S Ciceri, F Lancia, C Pasquini
Index: Bassetti, Mauro; Ciceri, Samuele; Lancia, Federico; Pasquini, Chiara Tetrahedron Letters, 2014 , vol. 55, # 9 p. 1608 - 1612
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Citation Number: 6
Abstract
Abstract The hydration of aromatic terminal alkynes performed in acetic acid in the presence of catalytic hydrate iron III sulfate, Fe 2 (SO 4) 3· nH 2 O (4–9 mol%), yields the derived aryl methyl ketones with good to excellent yields. Under comparable conditions (18 mol%, 95 C, 24 h), bifunctional substrates were transformed into the monoacetyl or the diacetyl derivatives, depending on the structure of the aromatic diyne. The reaction is compatible ...
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