Design of novel antibiotics that bind to the ribosomal acyltransfer site

J Haddad, LP Kotra, B Llano-Sotelo…

Index: Haddad, Jalal; Kotra, Lakshmi P.; Llano-Sotelo, Beatriz; Kim, Choonkeun; Azucena Jr., Eduardo F.; Liu, Meizheng; Vakulenko, Sergei B.; Chow, Christine S.; Mobashery, Shahriar Journal of the American Chemical Society, 2002 , vol. 124, # 13 p. 3229 - 3237

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Citation Number: 158

Abstract

The structure of neamine bound to the A site of the bacterial ribosomal RNA was used in the design of novel aminoglycosides. The design took into account stereo and electronic contributions to interactions between RNA and aminoglycosides, as well as a random search of 273 000 compounds from the Cambridge structural database and the National Cancer Institute 3-D database that would fit in the ribosomal aminoglycoside-binding ...