Palladium-catalyzed synthesis of symmetrical urea derivatives by oxidative carbonylation of primary amines in carbon dioxide medium

N Della Ca, P Bottarelli, A Dibenedetto, M Aresta…

Index: Ca', Nicola Della; Bottarelli, Paolo; Dibenedetto, Angela; Aresta, Michele; Gabriele, Bartolo; Salerno, Giuseppe; Costa, Mirco Journal of Catalysis, 2011 , vol. 282, # 1 p. 120 - 127

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Citation Number: 19

Abstract

An efficient palladium-catalyzed synthesis of symmetrically disubstituted ureas via oxidative carbonylation of primary amines is described. The reactions are carried out in the presence of a large excess of carbon dioxide as reaction medium or under solvent-free conditions. The adopted catalyst such as potassium tetraiodopalladate, stable and easy to prepare, allows the use of air as a cheap oxidizing agent. The reactions yield urea and water as the ...