Enzymatic and chemical syntheses of cis-dihydrodiol derivatives of monocyclic arenes

…, MV Hand, ND Sharma, J Chima, H Dalton…

Index: Boyd, Derek R.; Hand, Mark V.; Sharma, Narain D.; Chima, Jagdeep; Dalton, Howard; Sheldrake, Gary N. Journal of the Chemical Society, Chemical Communications, 1991 , # 22 p. 1630 - 1632

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Citation Number: 37

Abstract

Metabolism of bromobenzene and iodobenzene by growing cultures of Pseudomonas putida UV4 gave the corresponding cis-dihydrodiol products 1 and 2 in high yields; subsequent direct chemical substitution of the halogen atoms in these metabolites provided a new range of enantiomerically pure cis-dihydrodiols of known absolute configuration.