Solvent-free synthesis and structural characterization of azolyl-substituted pyrimidines

…, Á Díaz-Ortiz, J Elguero, C Foces-Foces…

Index: De la Hoz, Antonio; Blasco, Hector; Diaz-Ortiz, Angel; Elguero, Jose; Foces-Foces, Concepcion; Moreno, Andres; Sanchez-Migallon, Ana; Valiente, Gema New Journal of Chemistry, 2002 , vol. 26, # 7 p. 926 - 932

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Citation Number: 5

Abstract

Base-catalyzed trimerization of N-cyanomethylazoles under pressure and in solvent-free conditions afforded 4-amino-2, 6-bis (azol-1-ylmethyl)-5-(azol-1-yl) pyrimidines (1–3) in 33– 67% yields. The structures of these compounds was determined by a combination of NMR techniques and X-ray crystallography. The 4-amino groups show a restricted rotation around the C–N bond; the free energy of activation for this process was determined by variable ...