Flavone-based novel antidiabetic and antidyslipidemic agents

AK Verma, H Singh, M Satyanarayana…

Index: Verma, Alok K.; Singh, Himanshu; Satyanarayana, Mavurapu; Srivastava, Swayam P.; Tiwari, Priti; Singh, Amar B.; Dwivedi, Anil K.; Singh, Shio K.; Srivastava, Mukesh; Nath, Chandishwar; Raghubir, Ram; Srivastava, Arvind K.; Pratap, Ram Journal of Medicinal Chemistry, 2012 , vol. 55, # 10 p. 4551 - 4567

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Citation Number: 16

Abstract

The hybrid congeners 62–90 of 6-and 7-hydroxyflavones with aminopropanol have been synthesized and evaluated for their antidiabetic activity in sucrose-challenged low-dosed streptozotocin (STZ)-induced diabetic rats and db/db mice. The optical enantiomers 70a, 70b, 90a, and 90b of two congeners 70 and 90 exhibiting consistent antidiabetic and antidyslipidemic activities were also prepared, and their antidiabetic activity results ...