Efficient synthesis of mono-and diarylphosphinic acids: a microwave-assisted palladium-catalyzed cross-coupling of aryl halides with phosphinate

M Kalek, J Stawinski

Index: Kalek, Marcin; Stawinski, Jacek Tetrahedron, 2009 , vol. 65, # 50 p. 10406 - 10412

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Citation Number: 21

Abstract

Due to the presence of an active P–H bond, monoaryl-H-phosphinates can undergo an array of synthetically useful reactions, such as oxidation and oxidative couplings, 16 alkylation, 17 addition to carbonyl groups and imines, 18 hydrophosphinylation of multiple bonds, 19 and 20 or allylation 20 (Scheme 1, step c). Therefore, H-phosphinates represent versatile intermediates in the synthesis of various classes of arylated organophosphorus compounds.