Cu-mediated N-arylation of 1, 2, 3-triazin-4-ones: Synthesis of fused triazinone derivatives as potential inhibitors of chorismate mutase

…, D Rambabu, GR Krishna, CM Reddy, P Misra…

Index: Shiva Kumar; Adepu, Raju; Sandra, Sandhya; Rambabu; Rama Krishna; Malla Reddy; Misra, Parimal; Pal, Manojit Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1146 - 1150

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Citation Number: 14

Abstract

A rapid and direct access to N-aryl substituted fused triazinone derivatives has been accomplished via N-arylation of 1, 2, 3-triazin-4-one ring involving a Cu-mediated coupling between triazinone derivatives and aryl boronic acids. A combination of Cu (OAc) 2–Et3N in 1, 2-dichloroethane was found to be effective and various fused triazinone derivatives have been prepared by using this methodology. Molecular structure of a representative ...