Synthesis and biological activity of hydrochlorides of α-amino-α-H (phenyl)-(3-fluoro-4-methoxy) acetophenones

…, SA Gabrielyan, NA Apoyan, LP Podol'skaya…

Index: Gevorgyan, G. A.; Gabrielyan, S. A.; Apoyan, N. A.; Podol'skaya, L. P.; Sukasyan, R. S.; et al. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 12 p. 1004 - 1007 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 12 p. 1478 - 1480

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Abstract

The substituted acetophenones required for the synthesis of a-bromoketones (I) were prepared by acylation of 2-fluoroanisole with acetyl or phenylacetyl chloride. In the case of acylation of 4-fluoroanisole with acetyl chloride, we isolated, in addition to the 2-methoxy-5- fluoroacetophenone expected, 2-hydroxy-5-fluoroacetophenone (IV), which was subsequently converted to~-bromo-(2-hydroxy-5-fluoro) acetophenone (V) and then to~,- ...