Synthesis of 3-substituted and 3, 4-disubstituted pyrazolin-5-ones

JC Jung, EB Watkins, MA Avery

Index: Jung, Jae-Chul; Watkins, E.Blake; Avery, Mitchell A Tetrahedron, 2002 , vol. 58, # 18 p. 3639 - 3646

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Citation Number: 64

Abstract

The synthesis of 3-substituted and 3, 4-disubstituted pyrazolin-5-ones from acylated ethyl acetoacetates and diethyl malonates is described. The reaction of acylated ethyl acetoacetates and diethyl acetylmalonate with hydrazine (98%) gave 3-substituted pyrazolin- 5-ones and malonyldihydrazide, respectively, following a deacetylation–condensation sequence. The reaction of ethyl 2-acetyl-3-hydroxy-2-butenoate and diethyl 2-(1- ...