Analogs of pteroylglutamic acid. III. 4-amino derivatives

DR Seeger, DB Cosulich, JM Smith…

Index: Seeger et al. Journal of the American Chemical Society, 1949 , vol. 71, p. 1753,1757

Full Text: HTML

Citation Number: 240

Abstract

OH N-[4-([(2, 4-Diamino-6-pteridyl)-methyl]-amino)-IX IV benzoyl]-glutamic Acid (I)(“Aminopterin”).-A mixture of 27.4 g. of 2, 4, 5, 6-tetraminopyrimidine sulfate dihydrate,” 24.4 g. of barium chloride dihydrate and 500 ml. of woater was heated at 60” for ten minutes, then cooled to 45. 9-Aminobenzoyl-l (+)-glutamic acid (13, 3 9.) was added, and the PH was adjusted to 3 with 5 N sodlum hydroxidesolution. During twentyminutes21. 7 g. of 2, 3- ...