Synthesis of 4??Substituted??and 1, 4??Disubstituted??4??hydroxypyrrolidin??2??ones

CR Kinsinger, CD Tatko, CM Whelan…

Index: Kinsinger, Christopher R.; Tatko, Chad D.; Whelan, Christopher M.; Wilkinson, Timothy J. Synthetic Communications, 2007 , vol. 37, # 11 p. 1845 - 1852

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Abstract

This report describes the synthesis of 4??substituted?? and 1,4??disubstituted??4??hydroxypyrrolidin ??2??ones by cyclization of intermediate γ??aminoesters prepared from alkylbenzylamines, α??bromoketones, and lithio ethyl acetate. ... This report describes the synthesis of 4??substituted?? and 1,4??disubstituted??4??hydroxypyrrolidin??2??ones by cyclization of intermediate γ??aminoesters prepared from alkylbenzylamines, α??bromoketones, and lithio ethyl acetate.