Practical Synthesis of Enantiopure γ??Amino Alcohols by Rhodium??Catalyzed Asymmetric Hydrogenation of β??Secondary??Amino Ketones
D Liu, W Gao, C Wang, X Zhang
Index: Liu, Duan; Gao, Wenzhong; Wang, Chunjiang; Zhang, Xumu Angewandte Chemie - International Edition, 2005 , vol. 44, # 11 p. 1687 - 1689
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Citation Number: 75
Abstract
Enantioselective hydrogenation of amino ketones catalyzed by Ru–[1] or Rh–phosphine [2] complexes provides an efficient method for the synthesis of enantiomerically active amino alcohols, a class of chiral compounds of great importance in pharmaceutical products. A recent challenging target [3] inspired us to look for a practical solution for the enantioselective reduction of b-amino ketones with a secondary amino group, an ...
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