Tetrahedron Letters

An improved synthesis and some reactions of diethyl 4-oxo-4H-pyran-2, 5-dicarboxylate

DL Obydennov, GV Röschenthaler, VY Sosnovskikh

Index: Obydennov, Dmitrii L.; Roeschenthaler, Gerd-Volker; Sosnovskikh, Vyacheslav Ya. Tetrahedron Letters, 2013 ,  vol. 54,  # 48  p. 6545 - 6548

Full Text: HTML

Citation Number: 6

Abstract

Abstract The reaction of ethyl 2-(dimethylamino) methylene-3-oxobutanoate with diethyl oxalate in the presence of sodium hydride in THF gave diethyl 4-oxo-4H-pyran-2, 5- dicarboxylate, from which 4-oxo-4H-pyran-2, 5-dicarboxylic and 4-oxo-1-phenyl-1, 4- dihydropyridine-2, 5-dicarboxylic acids and their derivatives were obtained in good yields.