Tetrahedron

A microwave-enhanced, solventless Mannich condensation of terminal alkynes and secondary amines with para-formaldehyde on cuprous iodide doped alumina

GW Kabalka, LL Zhou, L Wang, RM Pagni

Index: Kabalka, George W.; Zhou, Li-Li; Wang, Lei; Pagni, Richard M. Tetrahedron, 2006 ,  vol. 62,  # 5  p. 857 - 867

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Citation Number: 44

Abstract

A microwave-enhanced, solventless Mannich condensation of terminal alkynes and secondary amines with para-formaldehyde on cuprous iodide doped alumina has been developed. β-Aminoalkynes are generated in good yields. The reaction can be extended to include a cyclization, which affords 2-substituted benzo [b] furans. The chemoselectivity of the reaction indicates that terminal alkynes are much more reactive than enolizable ...