Synthetic Applications of the Nickel??Catalyzed Cyclization of Alkynes Combined with Addition Reactions in a Domino Process

…, R Lhermet, M Rouen, J Maddaluno

Index: Durandetti, Muriel; Hardou, Lucie; Lhermet, Rudy; Rouen, Mathieu; Maddaluno, Jacques Chemistry - A European Journal, 2011 ,  vol. 17,  # 45  p. 12773 - 12783

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Citation Number: 14

Abstract

Abstract Carbonickelations of alkynes and functionalization of the resulting vinylnickel moiety have been performed efficiently in a nickel-catalyzed domino cyclization– condensation process. This reaction, which does not require the preparation of any other organometallic reagent, proceeds only by exo-dig cyclization. This convenient and mild method constitutes a one-pot synthesis of substituted dihydrobenzofurans, chromans, ...