Tetrahedron letters

New pyrazole containing bicarboxylic α-amino acids: mimics of the cis amide bond

L De Luca, M Falorni, G Giacomelli, A Porcheddu

Index: De Luca, Lidia; Falorni, Massimo; Giacomelli, Giampaolo; Porcheddu, Andrea Tetrahedron Letters, 1999 ,  vol. 40,  # 49  p. 8701 - 8704

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Citation Number: 27

Abstract

A series of novel optically active α-amino acids, containing a pyrazole ring, which can be regarded as building blocks for peptidomimetics, have been prepared starting from readily available α-amino acids. The synthetic strategy employed allows the regio-and stereoselective preparation of 1, 3-or 1, 5-substituted pyrazolyl rings. The pyrazole containing peptidomimetics can be considered as analogues of peptides with a cis amide ...