Synthesis and in vitro cytotoxicity of a series of 3-aminoflavones
D Dauzonne, B Folleas, L Martinez…
Index: Dauzonne; Folleas; Martinez; Chabot European Journal of Medicinal Chemistry, 1997 , vol. 32, # 1 p. 71 - 82
Full Text: HTML
Citation Number: 58
Abstract
To further understand the molecular requirements for the antiproliferative activity of flavonoids, a series of 3-amino-flavones and some of their derivatives were prepared and evaluated using L1210 murine leukemia. Our novel five-step synthetic approach required easily available substituted aromatic aldehydes as starting materials and proved more convenient and more general than previously reported methods. Our results in the 3- ...
Related Articles:
Flavonoids—38: Reaction of 2'-hydroxychalcone dibromides and-α-bromochalcones with azide ion
[Patonay,T.; Bognar,R. Tetrahedron, 1984 , vol. 40, p. 2555]
Synthesis of 3-aminoflavones from 3-hydroxyflavones via 3-tosyloxy-or 3-mesyloxyflavones
[Takechi, Atsushi; Takikawa, Hirosato; Miyake, Hideyoshi; Sasaki, Mitsuru Chemistry Letters, 2006 , vol. 35, # 1 p. 128 - 129]
Synthesis of 3-aminoflavones from 3-hydroxyflavones via 3-tosyloxy-or 3-mesyloxyflavones
[Takechi, Atsushi; Takikawa, Hirosato; Miyake, Hideyoshi; Sasaki, Mitsuru Chemistry Letters, 2006 , vol. 35, # 1 p. 128 - 129]