Synthesis and biological evaluation of polyhydroxycurcuminoids

S Venkateswarlu, MS Ramachandra…

Index: Venkateswarlu, Somepalli; Ramachandra, Marellapudi S.; Subbaraju, Gottumukkala V. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 23 p. 6374 - 6380

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Citation Number: 106

Abstract

A series of curcumin analogs (1–3, 5a–5t) was synthesized through the condensation of appropriately protected hydroxybenzaldehydes with acetylacetone, followed by deprotection. The antioxidant activity of these analogs was determined by superoxide free radical nitroblue tetrazolium and DPPH free radical scavenging methods and the polyhydroxycurcuminoids (5l–5s) displayed excellent antioxidant activity. These analogs ...