Amination, III. Trimethylsilanol as Leaving Group, V. Silylation—Amination of Hydroxy N??Heterocycles
H Vorbrüggen, K Krolikiewicz
Index: Vorbrueggen, Helmut; Krolikiewicz, Konrad Chemische Berichte, 1984 , vol. 117, # 4 p. 1523 - 1541
Full Text: HTML
Citation Number: 42
Abstract
Abstract Hydroxy N-heterocycles such as 18, 21, 26, and others are efficiently aminated in a one-step/one-pot procedure by silylation-amination to give 20, 23–25 etc. Silylation converts aromatic hydroxy N-heterocycles into activated and lipophilic intermediates of type 3, 8 which react in situ with ammonia, primary or secondary amines to form the corresponding mono-, bis-or tris-aminated products (5, 10). This addition-elimination of amines to O- ...
Related Articles:
A Practical and Easy Synthesis of 2, 4, 6-Trisubstituted-s-triazines
[Herrera, Antonio; Martinez-Alvarez, Roberto; Ramiro, Pedro; Chioua, Mourad; Chioua, Rachid Synthesis, 2004 , # 4 p. 503 - 505]
[Kolesinska, Beata; Kaminski, Zbigniew J. Tetrahedron, 2009 , vol. 65, # 18 p. 3573 - 3576]
Some Substituted Biguanides and s-Triazines1
[Detweiler; Amstutz Journal of the American Chemical Society, 1952 , vol. 74, p. 1483]