Palladium-catalyzed carbonyl insertion route to pyrido [2-1-b] quinazoline derivatives

…, DL Coffen, BH Schaer, J Lind

Index: Tilley, Jefferson W.; Coffen, David L.; Schaer, Beatrice H.; Lind, Joan Journal of Organic Chemistry, 1987 ,  vol. 52,  # 12  p. 2469 - 2474

Full Text: HTML

Citation Number: 32

Abstract

A synthesis of 8-substituted pyrido [2, 1-b] quinazoline derivatives is described involving as the key step the palladium-catalyzed carbonyl insertion reaction of 5-substituted 2-(2- bromoanilino) pyridines. This methodology provides a new and flexible route to the ppido [2, 1-b] quinazoline and related ring systems.